Masteron Enanthate, which should be more properly known as Drostanolone Enanthate, is a long estered variant of Drostanolone. Drostanolone was originally marketed on the prescription drug market under the brand name Masteron, which was Drostanolone Propionate (a short estered variant of Drostalonone. The trade name of Masteron caught on very quickly across bodybuilding circles, and the two should really be referred to as “Drostanolone Propionate” and “Drostanolone Enanthate” due to the fact that the brand name Masteron is really a descriptor for Drostanolone Propionate, and only Drostanolone Propionate. However, the Masteron trade name has stuck permanently onto the lips of bodybuilders and athletes everywhere, and so the Enanthate variant of Drostanolone is now referred to all the time as Masteron Enanthate. Chemically, the difference between Masteron Propionate and Masteron Enanthate is very much the exact same as the difference between Testosterone Propionate and Testosterone Enanthate. The base hormone, which in this case is Drostanolone, is affixed with an Enanthate ester on its 17-beta hydroxyl group.

The origins of Masteron Enanthate are not very clear at all. It is completely clear, however, that this is not and never ever was a pharmaceutical human grade product at all. Unlike similar products such as Trenbolone Enanthate that can be traced back to its first manufacture under specific underground labs (British Dragon), Masteron Enanthate has a far more shrouded history. It is currently unknown which underground labs, if any, originally introduced this product into the black market. There is some rumor that an underground lab by the name of Dpharm originally brought it into the market, but there is very little factual evidence to support these small rumors. Furthermore, it is not even entirely known when Masteron Enanthate hit the black market, though it was most likely during the early 2000s. This might make logical sense, considering the early 2000s was a period where a handful of underground laboratories (UGLs) were attempting to make headway into developing anabolic steroids that are beyond the scope of pharmaceutical application. Obviously the very first Masteron product (Masteron Propionate) entered the bodybuilding and athletic world by way of trickle-down from the pharmaceutical environment, but Masteron Enanthate seems to be a derivative resultant of the black market and underground world.

Masteron Enanthate is not even commonly listed in many anabolic steroid reference books either, demonstrating just how rare and infrequent the status and history is of this drug. Being that it never ever was even developed or tested in the pharmaceutical drug world, there is literally zero clinical data, nor any mention in any scientific literature of this drug to go by. Masteron (Drostanolone Propionate) was developed in 1959 by Syntex[1] and immediately upon release to the prescription market it was used almost exclusively for the treatment of female breast cancer patients. It eventually hit the bodybuilding and athlete steroid-using circles towards the 1970s – 1980s, and consequently during the 1980s all forms of Masteron were eventually pulled from the prescription market and discontinued. Masteron Propionate today is no longer manufactured as a pharmcaceutical grade product, and Masteron Enanthate was never even on the list of medicines produced by any pharmaceutical firms, ever. Masteron Propionate gained significant popularity towards the 1980s and 1990s and onwards, which is perhaps why eventually towards the early 2000s Masteron Enanthate came to fruition. Ultimately the same thing occurred with many similar anabolic steroids that started off as short-estered compounds and later were offered as long estered compounds of underground origin (such as Trenbolone).

To this day, however, the Propionate variant of Masteron remains the most commonly utilized and most popular variant, though the numbers of anabolic steroid users who now use Masteron Enanthate have increased substantially since the entrance of this product in the early 2000s on the black market.